Table II.
Summary of univariate and multivariate Cox proportional hazards analysis of OSCC DSS.
| Biomarker | Analysis | Hazard ratios, (95% CIs) |
|---|---|---|
| sCAIX (continuous) | Univariate | 1.014, (1.003–1.024) |
| Adjusted (age, sex and stage) | 1.010, (1.001–1.019) | |
| tCAIX (continuous) | Univariate | 1.003, (1.001–1.006) |
| Adjusted (age, sex and stage) | 1.002, (1.000–1.0005) | |
| Ki67 (continuous) | Univariate | 1.009, (0.995–1.023) |
| Adjusted (age, sex and stage) | 1.009, (0.995–1.024) | |
| tCAIX (dichotomized, 75%) | Univariate | 2.19, (1.25–3.83) |
| Adjusted (age, sex and stage) | 1.99, (1.13–3.50) | |
| sCAIX (dichotomized, 75%) | Univariate | 1.36, (0.74–2.51) |
| Adjusted (age, sex and stage) | 1.23, (0.68–2.23) | |
| Ki67 (dichotomized, median) | Univariate | 1.23, (0.73–2.06) |
| Adjus.ted (age, sex and stage) | 1.29, (0.75–2.21) |
OSCC, oral squamous cell carcinoma; CAIX, carbonic anhydrase IX; s, stromal; t, tumoral; CI, confidence interval; DSS, disease-specific survival.