Table 1.
Characteristics of eligible studies.
| First author (year) | Cases | Male/Female | age | Sample collection | Sample storage | Parameter | MINORS |
|---|---|---|---|---|---|---|---|
| Ai, WJ 2015 | 82 | 46/36 | 27.8 ± 2.8 | 6 | 4 °C, RT, 35 °C | HCT, HGB, MCHC, PLt, RBC, RDW, WBC | 22 |
| Bian, S 2014 | 50 | U | U | U | − 20 °C, 4 °C, RT | ALB, ALT, AST, CK, Cl, GLU, K, LDH, Na | 22 |
| Cai, J 2017 | 200 | 111/89 | 38.32 ± 6.46 | 1.5 | RT | GLU | 22 |
| Chen, C 2004 | 40 | 33/7 | 22–50 | U | RT | PLt, RBC, WBC | 22 |
| Cui, LN 2016 | 50 | 25/25 | 30.8 ± 7.7 | U | − 20 °C, 4 °C, RT | ALB, ALT, AST, CK, CO2, GLU, K, LDH, Na, TP | 22 |
| Cui, QL 2012 | 5 | U | U | U | 4 °C, RT | ALB, ALT, AST, BUN, CK, DBIL, GLU, TBIL, TC, TG, TP, UA | 22 |
| Cui, RG 2013 | 150 | 87/63 | 19–40 | 4 | RT | Ca, Cl, CO2CP, K, Na | 22 |
| Daves, M 2015 | 16 | 11/5 | 35–89 | U | 4 °C, RT, 35 °C | MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Deng, ZK 2012 | 30 | U | U | U | − 20 °C, 4 °C, RT | ALB, ALT, AST, CK, Cl, CO2, GLU, K, LDH, Na, TP | 22 |
| Dong LM 2014 | 200 | 100/100 | 38.7 ± 6.5 | 5 | RT | HGB, MCHC, MCV, PLt, RBC, WBC | 22 |
| Fan, YH 2015 | 88 | 56/32 | 37.2 ± 4.7 | 6 | RT | ALT, BUN, Cl, Cr, DBIL, GLU, K, Na, TBIL | 22 |
| Gao, HE 2015 | 86 | 44/42 | 37.5 ± 3.2 | 2 | RT | PLt, WBC | 22 |
| Gao, YH 2016 | 126 | 83/43 | 44.1412.93 | 8 | − 20 °C, 4 °C, RT | ALB, ALT, AST, CK, Cl, GLU, K, LDH, Na | 22 |
| Ge, LF 2009 | 50 | 25/25 | 34.5 | 2 | 4 °C | HCT, MCV, MPV, PLt, RBC, WBC | 22 |
| Gong, QH 2013 | 91 | 29/62 | 28–50 | 2 | 4 °C, RT | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Guo, HX 2017 | 200 | U | 51.6 ± 2.3 | U | RT | ALT, AST, CK, CK-MB, α-HBDH, GLU, LDH | 22 |
| Han, JP 2015 | 300 | 121/179 | 16–68 | U | RT | HGB, PLt, RBC, WBC | 22 |
| Hu, HJ 2013 | 10 | U | U | U | RT | ALP, ALT, AST, GGT, LDH | 22 |
| Hu, HY 2015 | 240 | U | U | U | RT | HGB, PLt, RBC, WBC | 22 |
| Huang, CQ 2013 | 200 | U | U | 2 | 4 °C, RT | HGB, PLt, RBC, WBC | 22 |
| Huang, SF 2014 | 160 | 80/80 | 31.2 ± 4.3 | 5 | RT | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Huang, XR 2012 | 40 | U | U | 4 | 4 °C | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Jia, DP 2016 | 90 | 55/35 | 30 ± 0.5 | U | 4 °C | HGB, PLt, RBC, WBC | 22 |
| Jiang, RR 2013 | 30 | U | U | 4 | 4 °C, RT | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Jiao, YH 2016 | 86 | 47/39 | 29.58 ± 7.15 | 20 | RT | ALT, AST, BUN, DBIL, GLU, K, Na, TBIL | 22 |
| Jin, LY 2011 | 30 | 13/17 | 20–60 | U | RT | HCT, HGB, MCH, MCHC, MCV, PLt, RBC, WBC | 22 |
| Kang, LX 2016 | 76 | U | U | RT | AST, CK, CK-MB, α-HBDH, GLU | 22 | |
| Li, M 2016 | 124 | 74/50 | 37.4 ± 8.2 | 2 | RT | ALT, AST, BUN, Ca, GLU, P, TBIL, TP | 22 |
| Li, N 2015 | 40 | 20/20 | 14–62 | 2 | 4 °C | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Li, QZ 2011 | 60 | 35/25 | 32.3 ± 8.3 | U | 4 °C, RT | RBC, Hb, HCT, WBC, PLt, RDW | 22 |
| Li, Y 2012 | 40 | U | U | 8 | − 20 °C, 4 °C, RT, − 80 °C | ALT | 22 |
| Li, YF 2015 | 160 | 94/66 | 35.11 ± 10.64 | 0.6 | RT | HGB, PLt, RBC, WBC | 22 |
| Li, YJ 2015 | 1000 | 500/500 | 31.57 ± 3.24 | U | − 20 °C | ALT, UA, ALB, BUN, TP, CR, TBIL, TC, CK | 22 |
| Li, ZS 2014 | 76 | 31/45 | 43.2 ± 11.8 | U | RT | PLt,WBC | 22 |
| Liang, Q 2004 | 40 | 16/24 | 45.7 | 2 | 4 °C, RT | HCT, HGB, MPV, PLt, RBC, RDW, WBC | 22 |
| Liu, HS 2006 | 20 | U | U | 4 | 4 °C | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Liu, QY 2008 | 60 | U | U | 2 | 4 °C | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Liu, W 2015 | 136 | 75/61 | 39.5 ± 6.5 | 3 | RT | WBC, RBC, PLt, Hb | 22 |
| Long, HX 2006 | 60 | 28/32 | 13–71 | U | 4 °C | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW | 22 |
| Ma, L 2013 | 30 | 18/12 | 22 ± 3 | 2 | 4 °C, RT, 35 °C | HCT, MCHC, RDW | 22 |
| Peng, HW 2010 | 157 | U | U | 5 | − 20 °C | ALB, ALT, AST, BUN, Cr, GLU, TBIL, TP, UA | 22 |
| Qian, M 2011 | 15 | U | U | U | RT | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Qu, SJ 2014 | 80 | 49/31 | 39.57 ± 3.67 | 10 | − 20 °C, RT, | BUN, Cl, Cr, α-HBDH, GLU, K, Na, PLt, TBIL | 22 |
| Rui, F 2015 | 120 | 86/52 | 33.75 ± 7.67 | U | RT | HGB, PLt, RBC, WBC | 22 |
| Shi, ZZ 2006 | 5 | U | U | 5 | 4 °C, RT | ALB, Cl, GLU, K, Na, TC, TG, TP, UA | 22 |
| Sirdah, MM 2013 | 25 | 25/0 | 18–20 | 20 | 4 °C, RT | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Su, QJ 2007 | 47 | 26/21 | 29.6 ± 8.4 | U | 4 °C, RT | HCT, HGB, MPV, PLt, RBC, RDW, WBC | 22 |
| Su, YH 2011 | 33 | U | U | U | RT | GLU | 22 |
| Sun, DJ 2015 | 160 | 89/71 | 46.3 ± 2.7 | 2 | RT | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, WBC | 22 |
| Tan, FS 2011 | 35 | 23/12 | 19–68 | 1 | RT | HGB, PLt, RBC, WBC | 22 |
| Tian ML 2015 | 100 | U | U | U | − 20 °C, 4 °C, RT | ALB, ALP, AST, CK-MB, DBIL, LDH, TBIL | 22 |
| Wang, J 2016 | 200 | 100/100 | 39.0 ± 9.6 | 5 | 4 °C, RT | HGB, PLt, RBC, WBC | 22 |
| Wang, LL 2016 | 30 | 13/17 | 18–43 | U | 4 °C, RT | HCT, HGB, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Wang, QP 2006 | 50 | 28/22 | 16–60 | U | 4 °C | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Wang, WS 2016 | 80 | 45/35 | 24–54 | 2 | RT | PLt, WBC | 22 |
| Wang, Y 2009 | 40 | 33/7 | 22–50 | U | RT | PLt, RBC, WBC | 22 |
| Wang, YG 2014 | 30 | 18/12 | U | 4 | 4 °C, RT | HGB, PLt, RBC, WBC | 22 |
| Wang, YJ 2011 | 80 | 40/40 | 19–40 | 5 | 4 °C | ALB, ALP, ALT, AST, BUN, Ca, Cl, GGT, GLU, K, Na, P, TBIL, TC, TG, TP | 22 |
| Wei, SF 2014 | 150 | 78/72 | U | U | 4 °C | ALP, ALT, AST, BUN, Ca, GGT, GLU, P, TBIL | 22 |
| Wei, SJ 2016 | 71 | 33/38 | 50.85 ± 5.85 | 2 | 4 °C, RT | HGB, PLt, RBC, WBC | 22 |
| Wen, XM 2008 | 10 | U | U | 5.5 | 4 °C, RT | HCT, HGB, MCH, MCHC, MCV, PLt, RBC, RDW, WBC | 22 |
| Wood, B L 1999 | 252 | U | U | U | 4 °C, RT | HCT, HGB, MCH, MCHC, MCV, PLt, RBC, WBC | 22 |
| Wu, HL 2011 | 33 | 15/18 | 18–68 | 3 | 4 °C | HCT, HGB, MCV, MPV, PLt, RBC, WBC | 22 |
| Wu, YY 2006 | 30 | 15/15 | 21–45 | 2 | 4 °C, RT | HCT, HGB, MCV, PLt, RBC, WBC | 22 |
| Xiao, XY 2013 | 70 | 45/25 | 23–26 | 2 | 4 °C, RT, 35 °C | HCT, MCHC, RDW | 22 |
| Xu, JF 2012 | 120 | 60/60 | 18–65 | U | 4 °C | ALB, ALP, ALT, AST, BUN, Ca, Cl, GGT, GLU, K, Na, P, TBIL, TC, TG, TP | 22 |
| Yan, F 2015 | 53 | 30/23 | 32.20 ± 5.45 | 10 | 4 °C, RT | ALB, GLU, K, TP, UA, | 22 |
| Yang, XR 2013 | 80 | 32/48 | 36.3 ± 3.9 | 4 | 4 °C | ALB, ALP, ALT, AST, TBIL, TG, TP | 22 |
| Yang, YM 2015 | 120 | U | U | U | 4 °C | ALP, ALT, AST, CK-MB, GLU, LDH | 22 |
| Yang, ZM 2016 | 60 | U | U | U | − 20 °C | ALB, ALT, AST, BUN, Cr, GLU, TBIL, TP, UA | 22 |
| Yao, L 2015 | 290 | 155/135 | 37.6 ± 6.5 | 1.5 | RT | GLU | 22 |
| Yi, JP 2014 | 68 | 37/31 | 43.7 ± 12.6 | U | − 20 °C | ALB, ALT, AST, BUN, Cr, GLU, TBIL, TP, UA | 22 |
| Yu, DQ 2015 | 86 | 47/39 | 29.58 ± 7.15 | 20 | RT | ALT, AST, BUN, DBIL, GLU, K, Na, TBIL | 22 |
| Yu, FR 2015 | 172 | 94/78 | U | 20 | RT | ALT, AST, BUN, DBIL, GLU, K, Na, TBIL | 22 |
| Yu, SQ 2003 | 60 | 34/26 | 19–65 | 0.5 | RT | HGB, PLt, RBC, WBC | 22 |
| Zeng, ZL 2007 | 30 | U | U | 5 | 4 °C, RT | ALB, ALP, ALT, AST, CK, Cr, DBIL, GLU, TBIL, TC, TG, TP, UA | 22 |
| Zhang, JS 2015 | 200 | 60/40 | 46.0 ± 2.0 | U | RT | ALT, AST, CK, CK-MB, C, Cr, α-HBDH, GLU, K, LDH, Na, TBIL, UA | 22 |
| Zhang, TY 2014 | 10 | U | U | 3 | 4 °C, RT | ALB, ALT, AST, BUN, CK, Cl, Cr, DBIL, α-HBDH, GLU, K, Na, TBIL, TC, TG, TP, UA | 22 |
| Zhang, YM 2014 | 86 | U | U | 2 | RT | ALT, AST, DBIL, TBIL | 22 |
| Zhang, ZQ 2005 | 10 | U | U | 15 | RT | Cl, CO2CP, GLU, K, Na | 22 |
| Zheng, G 2013 | 50 | U | U | U | − 20 °C | ALB, ALT, AST, BUN, Cr, GLU, TBIL, TP, UA | 22 |
| Zheng, HF 2016 | 120 | 60/60 | 29.6 ± 3.7 | U | 4 °C, RT | ALB, ALT, AST, BUN, CK, GLU, TBIL, TC, TG, TP | 22 |
| Zhou, YJ 2013 | 40 | U | U | U | 4 °C, RT | HGB, PLt, RBC, WBC | 22 |
| Zhou, YX 2006 | 50 | 18/32 | 14–70 | U | 4 °C | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW | 22 |
| Zhu, JH 2014 | 120 | 64/56 | 30.3 ± 2.1 | U | 4 °C, RT | ALB, ALT, AST, BUN, CK, GLU, TC, TP | 22 |
| Zhu, Q 2012 | 100 | 61/39 | 19.5 ± 8.5 | 8 | 4 °C, RT | GLU | 22 |
| Zhu, TL 2014 | 330 | U | 40.27 ± 11.06 | 3 | RT | ALT, AST, γ-GGT, TBIL | 22 |
| Zhu, WY 2011 | 86 | 40/46 | 4–82 | 2.5 | RT | HCT, HGB, MCH, MCHC, MCV, MPV, PLt, RBC, RDW, WBC | 22 |
| Zou, HY 2016 | 70 | 37/33 | 21–61 | 2 | RT | HGB, PLt, RBC, WBC | 22 |
Note: HCT: hematocrit; HGB: hemoglobin; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; MPV: mean platelet volume; PLt: platelet count; RBC: red blood cell count; RDW: RBC distribution width; WBC: white blood cell count; ALB: albumin; ALP: alkaline phosphatase; ALT: alanine amino transferase; AST: aspartate amino transferase; BUN: blood urea nitrogen; Ca: Calcium; CK: creatine kinase; CK-MB: creatine kinase isoenzymes; Cl: Chloride; CO2: carbon dioxide; Cr: creatinine; DBIL: direct bilirubin; α-HBDH: α- hydroxybutyrate; GGT: γ − -glutamyl transferase; GLU: glucose; K: potassium; LDH: lactate dehydrogenase; Na: sodium; P: phosphorus; TBIL: total bilirubin; TC: total cholesterol; TG: triglyceride; TP: total protein; UA: uric acid; MINORS: Methodological index for non-randomized studies.