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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Adv Exp Med Biol. 2017;953:49–82. doi: 10.1007/978-3-319-46095-6_2

Fig. 2.5.

Fig. 2.5

Spatially regulated translation of the Cripto-1 mRNA by the Bic-C repressor. (a) Bic-C represses the Cripto-1 mRNA in vegetal cells of Xenopus embryos. The Cripto-1 mRNA is translated in animal cells but repressed in vegetal cells. Vegetal cell repression requires Bic-C binding to its recognition element, a sequence within the Cripto-1 mRNA’s 3′UTR (Heasman 2006a; Houston 2013; Zhang et al. 2013, 2014). (b) The 32nt Bic-C binding site and its predicted stem-loop structure identified from the translational control element (TCE) of the Cripto-1 mRNA 3′UTR (Heasman 2006a; Zhang et al. 2014)