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Effect of hIL-1RA on LPS-induced hippocampal pro-inflammatory cytokines. Vehicle (0.9%) or LPS (100 μg/kg) was administered i.p. 4 d post-ICM injection of either vehicle (0.9%) or hIL-1RA (100 μg) and the hippocampal neuroinflammatory response measured 2 h post-LPS or vehicle treatment. Means with different letter designations (a, b, or c) are significantly different (p<.05) from each other. Data are presented as the mean±SEM.
