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. Author manuscript; available in PMC: 2017 Oct 23.
Published in final edited form as: Methods Mol Biol. 2012;851:99–107. doi: 10.1007/978-1-61779-561-9_6

Fig. 1.

Fig. 1

This picture shows the drilled troughs, with a catheter, made from PE-10 tubing, guided into place via the trough. The troughs are drilled 2–3 mm lateral of midline, and stop 1 mm posterior of bregma. The troughs are approximately 4 mm in length, gradually becoming deeper at the most posterior point. The skull is pierced and caution is taken not to penetrate the dura. Modified with permission from ref. 13.