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. Author manuscript; available in PMC: 2018 Apr 21.
Published in final edited form as: ACS Chem Biol. 2017 Feb 16;12(4):969–978. doi: 10.1021/acschembio.6b01015

Figure 5. Analogs weaken allosteric potency of MRL20.

Figure 5

EC50 values from a TR-FRET assay using TRAP220 coactivator peptide and His-PPARγ LBD ± covalent antagonist analogs. Data plotted as the average ± s.e.m. from the fit of the data to a sigmoidal dose-response equation.