Table 4. Agreement (contingency tables) between receptor status from IHC versus gene expression.

	estrogen ER		progesterone PGR		HER2
	GE–	GE+	GE–	GE+	GE–	GE+
IHC−	943	130	892	197	1573	14
IHC+	112	1084	184	487	305	233
log(DOR) ± 95%	4.25±0.27		2.48±0.23		4.45±0.55
Cohen's Kappa	0.79		0.54		0.52
Kruscal's Gamma	0.97		0.85		0.98
Rate of discordant samples	11%		22%		15%
Rate of conclusive samples	89%		78%		85%

Cut-points for gene expression were those derived by the ExMax-algorithm, see Table 3. Four measures of agreement are given: log(DOR) (natural logarithm of the Diagnostic Odds Ratio, DOR), Cohen's Kappa (inter-rater agreement), Kruscal's Gamma (strength of association) and the rate of discordant samples (conjugate to the rate of conclusive samples).