Table 1.

Comparison of symptoms, outcome and treatment in patients with PRES associated with oxaliplatin

Authors	Patients (age, sex)	Cancer type	Treatment	Symptoms and onset	Outcome
Skeleton et al13	19 F	Rectal adenocarcinoma	5-FU and oxaliplatin	Seizures and AMS	CRSSC, death later
Pinedo et al14	62 F	Rectal adenocarcinoma	Oxaliplatin, capecitabine, bevacizumab	Seizures, AMS, bilateral lower extremity weakness	CRSSC, bevacizumab continued without new symptoms
Nagata et al15	35 F	Sigmoid adenocarcinoma	Oxaliplatin, capecitabine	AMS, hypertension, seizures, headache, visual defects	CRSSC
Sharief and Perry16	59 M	Colon adenocarcinoma	Folinic acid, fluorouracil, oxaliplatin	AMS, seizures, status epilepticus	CRSSC
Chang et al17	–	Intrahepatic cholangiocarcinoma	Bevacizumab, gemcitabine, oxaliplatin	AMS, hypertension, proteinuria	–
Femia et al18	56 M	Colon adenocarcinoma	Oxaliplatin, capecitabine	Seizures, hypertension, AMS, renal impairment	Symptoms deteriorated, death later
Truman and Nethercott9	73 F	Caecal adenocarcinoma	Oxaliplatin, 5-FU	Severe occipital headache, AMS, after 48 hours develop hypertension, seizures,	CRSSC
Porcello et al19	27 F	Colorectal adenocarcinoma	Oxaliplatin, 5-FU, leucovorin	Hypertension, renal impairment, AMS	CRSSC, later died due to complications from cancer
Rahal et al20	50 M	Mixed adenoneuroendocrine carcinoma of appendix	Folinic acid, fluorouracil, oxaliplatin	AMS, seizures	CRSSC, seizures again on the original regimen, on changing to folinic acid, fluorouracil and irinotecan (FOLFIRI) no symptoms
Tang21	81 M	Colorectal adenocarcinoma	Oxaliplatin and capecitabine	AMS	CRSSC, she tolerated capecitabine only before starting oxaliplatin

5-FU, 5-flourouracil; AMS, altered mental status; CRSSC, complete resolution of symptoms after stopping chemotherapy; PRES, posterior reversible encephalopathy syndrome.