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. 2017 Nov;92(5):1223–1231. doi: 10.1016/j.kint.2017.04.029

Figure 4.

Figure 4

Serum creatinine level (a) and urine protein:creatinine ratio (uPCR) (b) at the time of biopsy were compared between the antineutrophil cytoplasmic antibody positive (ANCA+ve) and antineutrophil cytoplasmic antibody negative (ANCA−ve) groups. Lines indicate median ± interquartile range (IQR). Data were nonparametric, and comparative analyses were done using the Mann-Whitney U test (serum creatinine) or mixed analysis of variance (ANOVA) after transformation of data to achieve normal distribution (uPCR as repeated measures at different time points compared; see below). *P < 0.05. uPCR was also recorded at 6, 12, and 18 months post-biopsy (c). Data at all time points were normalized, and a mixed ANOVA was used to compare the change in uPCR over time between the ANCA+ve and ANCA−ve groups. Mean ± SEM are plotted for each time point. There was a significant decrease in proteinuria overall during the first 6 months post-biopsy (***significant difference [P < 0.001] compared with 6, 12, and 18 months). However, there was no significant difference between the ANCA+ve and ANCA−ve groups (P = 0.89). Neg, negative; Pos, positive.