Figure 1.

Boldface data represent significance at the P < 0.05 level. Mediation model to assess whether the associations of diabetes with brain volumes are mediated by cerebrovascular disease. A: If mediation by brain vascular pathology is present, paths 1–3 should be significantly associated and path 3 should be attenuated when also adjusted for the potential mediation (path 4). B: Weighted models adjusted for age, sex, race/field center, education, smoking status, hypertension, cardiovascular disease, APOE ε4 genotype, and total intracranial volume.