Table 3.
Weighted adjusted* cross-sectional associations of diabetes duration categories with brain MRI parameters among participants with diabetes, ARIC visit 5 (2011–2013) (n = 602)
| Diabetes duration <10 years (n = 342) | Diabetes duration ≥10 years (n = 260) | |
|---|---|---|
| Volumes†, β (95% CI) | ||
| Total brain | 0 (Reference) | −0.13 (−0.20, −0.05) |
| Frontal lobe | 0 (Reference) | −0.04 (−0.15, 0.06) |
| Temporal lobe | 0 (Reference) | −0.14 (−0.24, −0.03) |
| Occipital lobe | 0 (Reference) | −0.08 (−0.20, 0.04) |
| Parietal lobe | 0 (Reference) | −0.11 (−0.21, −0.01) |
| Deep gray matter | 0 (Reference) | −0.12 (−0.25, 0.02) |
| Alzheimer disease signature region | 0 (Reference) | −0.10 (−0.20, 0.01) |
| Hippocampus | 0 (Reference) | −0.16 (−0.30, −0.02) |
| Markers of subclinical cerebrovascular disease, OR (95% CI) | ||
| Lobar microhemorrhages | 1 (Reference) | 1.03 (0.50, 2.12) |
| Subcortical microhemorrhages | 1 (Reference) | 1.13 (0.69, 1.85) |
| Cortical infarcts | 1 (Reference) | 1.47 (0.76, 2.85) |
| Lacunar infarcts | 1 (Reference) | 2.44 (1.46, 4.05) |
| Log2 WMH volume†, β (95% CI) | 0 (Reference) | 0.18 (−0.03, 0.39) |
Boldface data represent P < 0.05.
*Model adjusted for age, sex, race/field center, education, smoking status, hypertension, cardiovascular disease, APOE ε4 genotype, and total intracranial volume (when outcome is volume).
†SD units. Definition of 1 SD: total brain volume 108.1 cm3, frontal lobe volume 16.0 cm3, temporal lobe volume 11.7 cm3, occipital lobe volume 5.5 cm3, parietal lobe volume 12.6 cm3, deep gray matter volume 4.3 cm3, Alzheimer disease signature region volume 7.0 cm3, hippocampal volume 1.0 cm3.