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. 2017 Aug 25;66(11):2875–2887. doi: 10.2337/db17-0215

Figure 3.

Figure 3

12/15-LOX inhibition protects against glycemic deterioration after multiple low-dose STZ injections. Nine-week-old male C57BL/6J mice were treated with vehicle or ML351. Multiple low-dose STZ injections (55 mg/kg) were given for 5 days (n = 5–15). A: Study design. B: Serum drug levels. C: Change in body weight from the start of the study. D: Random fed blood glucose measurements performed throughout the study. E: Results of GTTs performed at day 8. F: AUC from GTTs presented in E. G: GSIS in vivo. H: Results of ITTs performed at day 18. I: Area over the curve (AOC) from ITTs presented in H. Data are mean ± SEM. *P < 0.05 compared with no-STZ + M0. #P < 0.05 compared with STZ + M0.