Skip to main content
. 2017 Aug 25;66(11):2875–2887. doi: 10.2337/db17-0215

Figure 4.

Figure 4

Effect of 12/15-LOX inhibition on β-cell mass and serum insulin in the multiple low-dose STZ diabetes mouse model. Nine-week-old male C57BL/6J mice were treated with vehicle or ML351. Multiple low-dose STZ injections (55 mg/kg) were given for 5 days (n = 5–15). A: Representative images of pancreata immunostained for insulin (brown) and counterstained for hematoxylin (blue). Original magnification ×100; scale bars = 200 μm. B: β-Cell mass of pancreata harvested at day 21. C: Random fed serum insulin levels. Data are mean ± SEM. *P < 0.05 compared with no-STZ + M0.