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. 2017 Aug 25;66(11):2875–2887. doi: 10.2337/db17-0215

Figure 6.

Figure 6

12/15-LOX inhibition mitigates glycemic deterioration in prediabetic NOD mice. Six-week-old NOD and CD1 female mice were injected daily for 2 weeks with vehicle or 24 mg/kg ML351 (n = 5). A: GTTs performed at 8 weeks of age. B: AUC of GTTs presented in A. C: Random fed blood glucose at 8 weeks of age. D: Representative images of pancreata immunostained for insulin (brown) and counterstained with hematoxylin (blue) from prediabetic 8-week-old mice. Original magnification ×100; scale bars = 100 μm. E: β-Cell mass of pancreata harvested at week 8. F: Average insulitis score. G: Representative images of pancreata immunostained for glucagon (magenta), insulin (green), and DAPI (gray). Original magnification ×200; scale bars = 100 μm. *P < 0.05 compared with CD1 + M0. #P < 0.05 compared with NOD + M0. INS, insulin; NS, not significant.