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. 2017 Aug 25;66(11):2875–2887. doi: 10.2337/db17-0215

Figure 7.

Figure 7

12/15-LOX inhibition reduces islet oxidative stress in prediabetic NOD mice. Fixed pancreatic sections from CD1 and NOD mice treated with vehicle or 24 mg/kg ML351 were subjected to immunofluorescence staining. Shown are representative images and the pixel density or nuclear/cytoplasmic ratio from analysis of at least three animals per group. A: Oxidative stress marker 4-HNE (magenta), insulin (green), and DAPI (blue). B: Nrf2 (magenta), insulin (green), and DAPI (blue). C: Antioxidant enzyme GPX1 (magenta), insulin (green), and DAPI (blue). Original magnification ×200; scale bars = 100 μm. *P < 0.05 compared with CD1 + M0.