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Pharmacokinetic properties of ML351 in C57BL/6J mice
| Tissue | Cmax (ng/mL or ng/g)* | tmax (h) | AUC0-∞ (ng/mL ⋅ h or ng/g ⋅ h) | t1/2 (h) |
|---|---|---|---|---|
| IP injection | ||||
| Plasma | 454 | 1 | 1,106 | 9.4 |
| Brain | 119 | 4 | 1,573 | 5.2 |
| Fat | 5,293 | 4 | 67,798 | 4.6 |
| Liver | 131 | 4 | 1,837 | 6.2 |
| Pancreas | 255 | 4 | 3,199 | 4.1 |
| PO delivery | ||||
| Plasma | 135 | 1 | 698 | 21.4 |
| Brain | 159 | 4 | 1,941 | 3.3 |
| Fat | 620 | 4 | 7,835 | 4.3 |
| Liver | 157 | 4 | 1,911 | 3.1 |
| Pancreas | 57 | 4 | 700 | 3.4 |
*Data units presented as nanograms per milliliter plasma or nanograms/gram tissue weight.
