Figure 1.
The effect sizes of the established (blue diamonds, N = 69, P < 5 × 10−4) (Supplementary Material), novel (red diamonds, N = 13), and additional distinct (sky blue diamonds, N = 13) (Supplementary Table 7) signals according to their risk allele frequency (Supplementary Table 3). The additional distinct signals are based on approximate conditional analyses. The distinct signal at TP53INP1 led by rs11786613 (Supplementary Table 7) is plotted (sky blue diamond). This signal did not reach locus-wide significance but was selected for follow-up because of its low frequency and absence of LD with previously reported signal at this locus. The power curve shows the estimated effect size for which we had 80% power to detect associations. Established common variants with OR >1.12 are annotated.