Figure 1.

Discovery and replication of the rs149483638 T2D protective variant. Quantile-quantile plot for all common variants (A) and for Mexican population–specific variants (B). The plot shows the two most significant variants that have low frequency in Europeans but higher frequency in the Mexican population. C: Forest plot for the meta-analysis of rs149483638 variant in IGF2. We replicated the rs149483638 association in four independent data sets: 1,007 T2D case and 917 control subjects of Hispanic origin from T2D-GENES (MAF = 0.12, OR = 0.89, P = 0.3), 1,519 T2D case and 1,680 control subjects of full-heritage American Indian ancestry from the Pima cohort (MAF = 0.14, OR = 0.68, P = 1.09 × 10⁻⁵), 427 case and 751 control subjects of self-identified indigenous individuals from different ethnic groups in Mexico (DMS2 cohort) (MAF = 0.36, OR = 0.71, P = 0.001), and 1,064 case and 4,832 control subjects from the subset of subjects with Latino ancestry from the GERA cohort (MAF = 0.06, OR = 0.82, P = 0.11).