Figure 5.

Phenome-wide analysis of rs149483638 variant. The protective variant was tested for association across 18 different disease traits previously categorized in the subsample of GERA cohort of Latino ancestry (5,896 individuals). Although the rs149483638 variant was associated with reduced risk of T2D, there was no significant association seen for other 18 conditions. Association analyses were done by logistic regression analyses, considering additive model, and correcting for age, BMI, sex, and the first two principal components to correct for population stratification. IBS, irritable bowel syndrome; Mac. Degen., macular degeneration; Psychiatric, any psychiatric condition; PVD, peripheral vascular disease; Stress, acute reaction to stress.