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A. NLRP3 is induced in WT mice by albumin loading and is induced in the NKCC2 expression tubules B. C. Western blots of NKCC2. D. Densitometric analysis of NKCC2. E. Immunohistochemistry of NKCC2, qualitatively, demonstrates the NLRP3 dependence of albumin-induced NKCC2 expression. The values represent the means±SDs (n=6). * p<0.01 vs. WT or NLRP3−/− control mice. # p<0.01 vs. albumin-overloaded WT mice.
