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. 2016 Jun 23;8(44):75808–75821. doi: 10.18632/oncotarget.10257

Figure 7. Physiologic study to test the diuretic response of albumin-overloaded WT and NLRP3-/- mice to the NKCC2 inhibitor furosemide (F).

Figure 7

A–D. WT and NLRP3−/− mice were treated with either saline or albumin for up to 12 days and their diuretic response to vehicle (V) or furosemide measured over 6 hr. NLRP3 deletion reversed the blunted response to furosemide in albumin-overloaded mice. (A) Urine volume, (B) urinary sodium excretion, (C) urinary chloride excretion, and (D) urinary potassium excretion. The values represent the means±SDs (n=6 in each group). * p<0.01 vs. vehicle-treated WT or NLRP3−/− mice without albumin overload (day0). # p<0.01 vs. furosemide-treated WT mice without albumin overload (day0). Δ p<0.01 vs. furosemide-treated WT mice following albumin overload for 9 days(day9) or 12 days (day12).