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CPA (140 mg/kg, i.p., qw×3); TEM (25 mg/kg, p.o., qd×21); TEM (25 mg/kg, p.o., qd×21) combined with IRN (4 mg/kg, i.p., qd×21). Tumor volume was measured at the indicated time points after the onset of treatment. Please see the Materials and Methods for details. N = 8 mice/group. *P=0.0002; **P<0.0001.
