Table 5. Serial changes of circulating microparticles between chemotherapy and target therapy patients.
| Variables | Chemotherapy (n=65) | Target therapy (n=71) | P-value |
|---|---|---|---|
| PDAc-MPs (time 1)* | 223983.58 ± 1022792.58 | 149054.89 ± 224562.98 | 0.548 |
| PDAp-MPs (time 1)* | 44645.09 ± 136502.00 | 18485.23 ± 13633.03 | 0.129 |
| EDAc-MPs (time 1)* | 9618.75 ± 46275.14 | 9478.30 ± 12246.30 | 0.417 |
| EDAp-MPs (time 1)* | 42145.84 ± 15114.76 | 13461.90 ± 10052.02 | 0.132 |
| PDAc-MPs (time 2)† | 73103.35 ± 109872.19 | 93987.94 ± 91086.41 | 0.228 |
| PDAp-MPs (time 2)† | 16885.72 ± 17225.25 | 17386.25 ± 14031.42 | 0.852 |
| EDAc-MPs (time 2)† | 2613.71 ± 4444.46 | 3263.08 ± 3412.56 | 0.339 |
| EDAp-MPs (time 2)† | 11468.14 ± 7389.82 | 12879.21 ± 8241.49 | 0.297 |
| PDAc-MPs (time 3)‡ | 119051.69 ± 250550.43 | 61049.11 ± 83443.71 | 0.034 |
| PDAp-MPs (time 3)‡ | 24724.68 ± 36663.15 | 14472.15 ± 14869.75 | 0.039 |
| EDAc-MPs (time 3)‡ | 7070.12 ± 16525.59 | 2285.21 ± 2554.22 | 0.024 |
| EDAp-MPs (time 3)‡ | 15424.49 ± 12684.86 | 10738.13 ± 7661.49 | 0.011 |
Data expressed as mean ± SD.
PDAc-MPs = platelet-derived activated microparticles; PDAp-MPs = platelet-derived apoptotic MPs; EDAc-MPs = endothelial-derived activated MPs; EDAp-MPs = endothelial-derived apoptotic MPs.
* indicated the blood sampling was performed prior to any treatment. † indicated the blood sampling was performed at the end of 1st month after pharmacological intervention. ‡ indicated the blood sample was performed at the end of the 3rd month after pharmacological intervention.