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. 2017 Jun 6;8(44):75968–75978. doi: 10.18632/oncotarget.18373

Table 2. Biologic pathways enriched by differentially expressed exosomal miRNAs.

KEGG pathway p-value
Prion diseases (hsa05020) 2.820E-09
Signaling pathways regulating pluripotency of stem cells (hsa04550) 2.820E-09
Proteoglycans in cancer (hsa05205) 6.454E-09
 Adherens junction (hsa04520) 2.600E-07
 ECM-receptor interaction (hsa04512) 4.887E-07
Hippo signaling pathway (hsa04390) 5.721E-07
 TGF-beta signaling pathway (hsa04350) 2.408E-06
 Axon guidance (hsa04360) 1.494E-05
 Rap1 signaling pathway (hsa04015) 2.388E-05
Pathways in cancer (hsa05200) 4.904E-05
 Prostate cancer (hsa05215) 9.959E-05
Transcriptional misregulation in cancer(hsa05202) 1.580E-04
 Endocytosis (hsa04144) 2.308E-04
 Oocyte meiosis (hsa04114) 2.410E-04
 Regulation of actin cytoskeleton (hsa04810) 3.968E-04
 Focal adhesion (hsa04510) 5.100E-04
 Thyroid hormone signaling pathway (hsa04919) 6.869E-04
 Bacterial invasion of epithelial cells (hsa05100) 9.954E-04
 Glutamatergic synapse (hsa04724) 9.954E-04
PI3K-Akt signaling pathway (hsa04151) 1.011E-03
Ras signaling pathway (hsa04014) 1.515E-03
 Melanoma (hsa05218) 1.708E-03
 Glioma (hsa05214) 1.872E-03
 GABAergic synapse (hsa04727) 1.959E-03
 Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412) 2.330E-03
 Gap junction (hsa04540) 4.817E-03
 FoxO signaling pathway (hsa04068) 5.137E-03
 Thyroid cancer (hsa05216) 5.369E-03
 Inositol phosphate metabolism (hsa00562) 7.351E-03
 Acute myeloid leukemia (hsa05221) 8.747E-03
 Mucin type O-Glycan biosynthesis (hsa00512) 9.315E-03
 Wnt signaling pathway (hsa04310) 9.315E-03
 Colorectal cancer (hsa05210) 1.070E-02
 Long-term potentiation (hsa04720) 1.070E-02
 Adrenergic signaling in cardiomyocytes(hsa04261) 1.285E-02
 Oxytocin signaling pathway (hsa04921) 1.620E-02
 Amphetamine addiction (hsa05031) 1.954E-02
 Shigellosis (hsa05131) 2.067E-02
 Long-term depression (hsa04730) 2.067E-02
 Dorso-ventral axis formation (hsa04320) 2.232E-02
 Phosphatidylinositol signaling system (hsa04070) 2.575E-02
Ubiquitin mediated proteolysis (hsa04120) 2.832E-02
 mRNA surveillance pathway (hsa03015) 3.431E-02
 ErbB signaling pathway (hsa04012) 3.431E-02
 Mineral absorption (hsa04978) 4.049E-02
Choline metabolism in cancer (hsa05231) 4.363E-02
 Endocrine and other factor-regulated calcium reabsorption (hsa04961) 4.613E-02
 Chronic myeloid leukemia (hsa05220) 4.944E-02