Table 3. Univariate and multivariate analyses of NEDD9, BCAR1 and clinical variables in CIR.
| Cohort 1 (n = 59) | Cohort 2 (n = 185) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CIR | Univariate | Multivariate | Univariate | Multivariate | |||||||||
| Variable | Item | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
| Age | < 50 years | 1 | 1 | ||||||||||
| > 50 years | 1.160 | (0.453–2.970) | 0.760 | – | – | – | 1.080 | (0.656–1.770) | 0.770 | – | – | – | |
| Sex | Male | 1 | 1 | ||||||||||
| Female | 0.842 | (0.326–2.180) | 0.720 | – | – | – | 1.030 | (0.634–1.680) | 0.900 | – | – | – | |
| WBC | < 20 × 109/l | 1 | 1 | ||||||||||
| >20 × 109/l | 2.110 | (0.710–6.250) | 0.180 | 2.080 | (0.623–6.940) | 0.230 | 1.090 | (0.672–1.780) | 0.720 | – | – | – | |
| FLT3 | FLT3/ITD− | 1 | 1 | ||||||||||
| FLT3/ITD+ | 1.300 | (0.714–2.370) | 0.390 | – | – | – | 1.720 | (1.100–2.680) | 0.016 | 1.660 | (0.911–3.024) | 0.098 | |
| NPM1 | NPM1− | 1 | 1 | ||||||||||
| NPM1+ | 0.875 | (0.456–1.680) | 0.690 | – | – | – | 0.814 | (0.501–1.320) | 0.410 | – | – | – | |
| FLT3/NPM1 | Favorable | 1 | 1 | ||||||||||
| Unfavorable | 6.360 | (0.903–44.700) | 0.063 | 6.050 | (0.870–42.050) | 0.069 | 2.030 | (1.140–3.620) | 0.016 | 1.615 | (0.855–3.052) | 0.140 | |
| NEDD9 | Underexpression | 1 | 1 | ||||||||||
| Overexpression | 0.606 | (0.185–1.990) | 0.410 | – | – | – | 0.519 | (0.278–0.969) | 0.040 | 0.441 | (0.220–0.884) | 0.021 | |
| BCAR1 | Underexpression | 1 | 1 | ||||||||||
| Overexpression | 0.578 | (0.134–2.490) | 0.460 | – | – | – | 0.767 | (0.409–1.440) | 0.410 | – | – | – | |
Gray and Fine and Gray tests for CIR were used to analyze the statistical significance. P value < 0.05 was considered statistically significant (Bold values). “–“ indicates that variables were not included in the multivariate analyses (P value > 0.250 in the univariate analysis). HR; Hazard ratio. CI; Confidence interval. CIR; Cumulative incidence of relapse. WBC; White blood cells.