Table 4. Association between NEDD9 expression and clinical data in the cohorts of our study.
| Parameter | Cohort 1 | NEDD9 | Cohort 2 | NEDD9 | ||||
|---|---|---|---|---|---|---|---|---|
| Total (n = 73) | Under-expressed | Over-expressed | p-value | Total (n = 204) | Under-expressed | Over-expressed | p-value | |
| Age, | 73 | 55 | 18 | 0.726† | 204 | 153 | 51 | 0.405† |
| < 50 years (%) | 34 (47) | 27 | 7 | 0.588 | 87 (43) | 63 | 24 | 0.514 |
| > 50 years (%) | 39 (53) | 28 | 11 | 117 (57) | 90 | 27 | ||
| Sex, | ||||||||
| Male (%) | 39 (53) | 29 | 10 | 1.000 | 108 (53) | 87 | 21 | 0.074 |
| Female (%) | 34 (47) | 26 | 8 | 96 (47) | 66 | 30 | ||
| WBC, | 73 | 55 | 18 | 0.774‡ | 202 | 151 | 51 | 0.818‡ |
| <20 × 109/L (%) | 25 (34) | 18 | 7 | 0.776 | 107 (53) | 82 | 25 | 0.521 |
| >20 × 109/L (%) | 48 (66) | 37 | 11 | 95 (47) | 69 | 26 | ||
| FAB Classification, (%) | 0.026* | 0.029* | ||||||
| M0 | 8 (11) | 7 | 1 | 16 (8) | 14 | 2 | ||
| M1 | 23 (32) | 21 | 2 | 46 (22) | 39 | 7 | ||
| M2 | 6 (8) | 6 | 0 | 41 (20) | 33 | 8 | ||
| M4 | 12 (16) | 8 | 4 | 36 (18) | 28 | 8 | ||
| M4E | 1 (1) | 1 | 0 | 1 (1) | 1 | 0 | ||
| M5 | 21 (29) | 10 | 11 | 46 (22) | 27 | 19 | ||
| M6 | 1 (1) | 1 | 0 | 6 (3) | 5 | 1 | ||
| M7 | 1 (1) | 1 | 0 | 0 (0) | 0 | 0 | ||
| Protein mutations, (%) | ||||||||
| FLT3/ITD− | 39 (53) | 30 | 9 | 1.000 | 149 (73) | 116 | 33 | 0.198 |
| FLT3/ITD+ | 29 (40) | 22 | 7 | 54 (27) | 37 | 17 | ||
| NPM1− | 31 (43) | 22 | 9 | 0.779 | 108 (53) | 85 | 23 | 0.257 |
| NPM1+ | 33 (45) | 25 | 8 | 95 (47) | 68 | 27 | ||
| FLT3− + NPM1+ (Fav.) | 16 (22) | 12 | 4 | 1.000 | 60 (30) | 43 | 17 | 0.476 |
| Others (Unfav.) | 47 (64) | 35 | 12 | 143 (70) | 110 | 33 | ||
| Alive (%) | 35 (48) | 22 | 13 | 0.028 | 105 (51) | 72 | 33 | 0.035 |
| Death (%) | 38 (52) | 33 | 5 | 99 (49) | 81 | 18 | ||
| No relapse (%) | 42 (71) | 31 | 11 | 0.737 | 129 (67) | 93 | 36 | 0.152 |
| Relapse (%) | 17 (29) | 14 | 3 | 63 (33) | 52 | 11 |
Results are presented as the number of patients for each characteristic. The percentage of the patients is indicated in brackets for each condition. For categorical variables, the Fischer exact test or χ2 test (*) were used to analyze the statistical significance; while for continuous variables showing normal or abnormal distribution, the Student's t-test (†) or the Mann-Whitney U (‡) test were used, respectively. P < 0.05 indicates statistical significance (Bold values). WBC; White blood cells. FAB; French-American-British.