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. 2017 Jun 16;8(44):76085–76098. doi: 10.18632/oncotarget.18543

Figure 2. The novel tropolones induce cytotoxic effects in myeloma cells.

Figure 2

(A) MTT assays were performed following a 48-hour incubation period with the tropolones in RPMI-8226 cells. (B) Time-dependent effects of MO-OH-Nap in RPMI-8226 cells. Data are expressed as percentage of control (mean + standard deviation, n = 4). (C) U266 and (D) RPMI-8226 cells were treated with DMSO (solvent control) or MO-OH-Nap for 48 hours. Cells were stained with fluorescently conjugated Annexin V and 7-AAD and analyzed by flow cytometry. Data are expressed as the average percentage of Annexin V-positive, 7-AAD-negative cells (n = 3, error bars denote standard deviation, *denotes p < 0.05. **denotes p < 0.01).