Table 1. Cytotoxic activity of the novel α-substituted tropolones.

	MTT assay IC50 (μM) (48-hour incubation)
	RPMI-8226	U266	MM.1S
MO-OH-Nap	1.2	11	10
HC-1-OH	2.4	89	24
BA-SM-OH	0.5	68	3.9
BA-pOH-OH	4.4	> 100	68
Am-piv-OH	2.2	> 100	23
BA-HC2-OH	2.2	18	6.8
SAHA	1.01	2.96	0.93

IC₅₀ values for myeloma cells treated with various tropolone derivatives or SAHA are shown.