Table 2. Ingenuity pathway analysis: Top canonical pathways.
| MOOH-24 hr vs Control | ||
|---|---|---|
| Pathway | p-value | Overlap |
| Glycolysis I | 4.98E-10 | 32.0% (8/25) |
| Gluconeogenesis I | 1.80E-08 | 28.0% (7/25) |
| Unfolded protein response | 3.50E-07 | 14.8% (8/54) |
| Sucrose Degradation V (Mammalian) | 1.55E-04 | 33.3% (3/9) |
| Cysteine Biosynthesis/Homocysteine Degradation | 1.57E-04 | 100.0% (2/2) |
| MOOH-48 hr vs Control | ||
| Pathway | p-value | Overlap |
| Unfolded protein response | 6.53E-12 | 25.9% (14/54) |
| Endoplasmic Reticulum Stress Pathway | 1.99E-07 | 33.3% (7/21) |
| Antigen Presentation Pathway | 1.36E-04 | 16.2% (6/37) |
| Estrogen-mediated S-phase Entry | 1.45E-04 | 20.8% (5/24) |
| Glucocorticoid Receptor Signaling | 2.03E-04 | 5.9% (17/287) |
| Saha-24 hr vs Control | ||
| Pathway | p-value | Overlap |
| Cell Cycle Control of Chromosomal Replication | 6.41E-07 | 21.1% (8/38) |
| Estrogen-mediated S-phase Entry | 5.78E-06 | 5.0% (6/24) |
| Germ Cell-Sertoli Cell Junction Signaling | 4.28E-05 | 7.5% (13/173) |
| Actin Nucleation by ARP-WASP Complex | 1.14E-04 | 12.5% (7/56) |
| Cyclins and Cell Cycle Regulation | 1.54E-04 | 10.3% (8/78) |
Differentially expressed genes (DEG) were analyzed using Ingenuity Pathway Analysis. The top hit for “Canonical Pathways” are shown, as well as the associated p-value and number of DEG that overlap with each pathway. A p-value < 0.05 was considered significant.