Table 2. Analysis of the association of the APOBEC3B deletion with ovarian cancer risk using dominant model of inheritance (A3B+/− and A3B−/− vs. A3B+/+).
| Group | Genotypes | No of cases(%) | No of controls(%) | OR(95%CI) | AdjustedOR(95%CI) |
|---|---|---|---|---|---|
| GDANSK: OCcases (n=343)vs. unselected controls(n=853) | A3B+/+ | 313 (91.25%) | 759 (88.98%) | 0.77(0.50-1.19)p=0.24 | - |
| A3B+/− | 28 (8.16%) | 91 (10.67%) | |||
| A3B−/− | 2 (0.58%) | 3 (0.35%) | |||
| A3B+/− and A3B−/− | 30 (8.75%) | 94 (11.02%) | |||
| VILNIUS: OCcases (n=97)vs. unselected controls(n=209) | A3B+/+ | 90 (92.78%) | 187 (89.47%) | 0.66(0.27-1.61)p=0.36 | - |
| A3B+/− | 6 (6.19%) | 22 (10.53%) | |||
| A3B−/− | 1 (1.03%) | 0 (0%) | |||
| A3B+/− and A3B−/− | 7 (7.22%) | 22 (10.53%) | |||
| GDANSK + VILNIUS: OCcases (n=440)vs. unselected controls(n=1062) | A3B+/+ | 403 (91.59%) | 946 (89.08%) | 0.75(0.51-1.10)p=0.14 | 0.75(0.51-1.11)bp=0.15 |
| A3B+/− | 34 (7.73%) | 113 (10.64%) | |||
| A3B−/− | 3 (0.68%) | 3 (0.28%) | |||
| A3B+/− and A3B−/− | 37 (8.41%) | 116 (10.92%) |
bAdjusted for the origin of the study.