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. 2017 Aug 28;8(44):76558–76573. doi: 10.18632/oncotarget.20576

Figure 7. FXR deficiency accelerates OVX-induced bone loss in vivo.

Figure 7

Female 12-week-old mice underwent either OVX or sham operation, and mouse femurs were collected after 10 weeks. (A) Two-dimensional micro-CT images of the distal metaphysis of the femurs. (B) BMD (g/cm2) of femur from FXR+/+ and FXR−/− mice was analyzed by DXA. (C–G) Various bone parameters of femurs were analyzed by micro-CT. BV/TV (%) (C), Tb.Th (mm) (D), Tb.N (/mm) (E), SMI (F), Tb.Sp (mm) (G). (I) A simplified model for the role of FXR in osteoclastogenesis. *p < 0.05, **p < 0.01. N.S.: Not Significant.