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. 2017 Aug 29;8(44):76574–76586. doi: 10.18632/oncotarget.20580

Figure 5. CREB expression in tumor xenografts by IHC.

Figure 5

IHC confirmed the presence of CREB expression in CRC (HT29) and (SW480) (A). Compared to primary CRC lesion, the expression of CREB was markedly increased in metastatic CRC lesions (A). IHC confirmed the expression status of CD31, CREB, and p53 in CRC (HT29) and (SW480) (B). Compared to R72 CRC, the expression of CD31 (tumor angiogenesis) or CREB was markedly increased in P72 CRC. Sequencing analysis revealed that LS174T or HT29 tumors exhibit homozygous for Arg/Arg, whereas SW480 tumor exhibits homozygous for Pro/Pro (B). IHC analysis revealed that LS174T tumor was found to be negative for p53 expression (p53 wild type) (B), whereas HT29 or SW480 tumors were found to be positive for p53 expression (p53 mutants) (B).