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. 2017 Aug 29;8(44):76574–76586. doi: 10.18632/oncotarget.20580

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Copyright: © 2017 Katkoori et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Immunostaining confirmed the presence of CREB expression in CRC (A). Compared to normal, the expression of CREB was markedly increased in primary CRC lesion or metastatic CRC lesions (A). (B) IHC confirmed the expression status of CD31, CREB, and p53 in CRC (B). Compared to R72 CRC, the expression of CD31 (tumor angiogenesis) or CREB was markedly increased in P72 CRC. IHC analysis revealed that tumors were found to be negative for p53 expression (p53 wild type) (B).