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. 2017 Aug 10;8(44):76865–76880. doi: 10.18632/oncotarget.20172

Figure 4. 5-Aza abrogated perinatal nicotine-induced heightened global DNA methylation levels in the LV tissues of male offspring.

Figure 4

Pregnant rats were treated with saline (control) or nicotine, and pups were administered with 5-Aza (i.p. 1mg/kg/day) on postnatal day 3, 7 and 10 after delivered. At one month of age, the global DNA methylation was qualified by 5-mC ELISA in the left ventricle tissues isolated from male offspring. Data are means ± SEM (n = 4-6 animals/group from different litter). * P < 0.05 vs control. # P < 0.05 vs -5-Aza.