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. 2017 Aug 24;8(44):77207–77218. doi: 10.18632/oncotarget.20430

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Copyright: © 2017 Menyhart et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Normalized viability of SKTR and JIMT-1 cells treated with 10 μg/mL trastuzumab (T) after DUSP4 and DUSP6 silencing compared to Negative control siRNA (sc-siRNA) treated cells (mean with SEM) and (B) simplified scheme of the targets of DUSP4 and DUSP6. DUSP4 potentially promotes both survival and apoptosis by dephosphorylating ERK, JNK and p38.