Table 1. Binding free energies (ΔGbind) and binding free energy differences (ΔΔGbind) for the Hsp27 WT, N1, N2 and C2 truncated mutants in complex with eIF4E. (ΔΔGbind=ΔGbind(WT)- ΔGbind(truncated)).
Complex | ΔGbind(kcal/mol) | ΔΔGbind(kcal/mol) |
---|---|---|
Hsp27 WT | -11.86 ± 0.24 | - |
Hsp27 N1 | -3.06 ± 0.27 | -8.80 |
Hsp27 N2 | -6.05 ± 0.23 | -5.81 |
Hsp27 C1 | -9.99 ± 0.25 | -1.87 |