Figure 6. NR4A2 mediated autophagy-dependent apoptosis in H₂O₂-induced autophagy and apoptosis in CSCs.

(A) CSCs were transfected with LV3-NC or LV3-siNR4A2 for 48 h, then pretreated with Rapamycin for 30 min followed by H₂O₂ treatment for another 5 h. cleavage of caspase 3 and PARP1, and LC3-II were detected by western blot. *P < 0.05; **P < 0.01; n=3.