| AHCTF1 |
Putative AT-hook-containing transcription factor |
36.5% |
14.6% |
0.1% |
29.6% |
0.4% |
1.6% |
| AURKA |
Microtubule formation and/or stabilization, centrosome homeostasis |
20.4% |
5.6% |
0.0% |
18.6% |
0.0% |
0.5% |
| BIRC5 |
Inhibitor of apoptosis (IAP) gene family |
15.3% |
6.2% |
0.1% |
12.9% |
0.0% |
0.0% |
| BRCA1 |
DNA repair, centrosome amplification, chromosome instability |
13.5% |
1.8% |
0.8% |
9.7% |
0.0% |
2.5% |
| BUBR1 |
Spindle checkpoint |
8.7% |
0.4% |
1.1% |
7.0% |
0.0% |
0.3% |
| CP110 |
Centriolar protein |
16.5% |
4.3% |
0.0% |
13.6% |
0.0% |
0.4% |
| CDC16 |
Ubiquitin ligase, component of the APC complex |
24.6% |
2.5% |
0.7% |
9.1% |
14.9% |
0.3% |
| CDC6 |
Early DNA replication |
15.3% |
6.5% |
0.3% |
13.3% |
0.0% |
0.3% |
| CENPF |
Centromere-kinetochore, spindle, midzone |
25.5% |
12.5% |
0.0% |
15.6% |
0.0% |
1.3% |
| CENPL |
Kinetochore, mitotic progression |
28.1% |
10.0% |
0.0% |
22.0% |
0.0% |
0.5% |
| CEP250 |
Centriole-centriole cohesion |
18.4% |
2.8% |
0.1% |
15.0% |
1.3% |
1.2% |
| CREBBP |
Histone acetyl-transferase, transcriptional co-activation |
20.8% |
5.1% |
0.4% |
14.0% |
1.9% |
2.0% |
| CSNK1D |
DNA replication and repair, apoptosis, microtubule dynamics, chromosome segregation |
16.8% |
6.2% |
0.6% |
10.1% |
3.4% |
0.1% |
| DSN1 |
Kinetochore assembly and progression through the cell cycle |
15.9% |
2.0% |
0.0% |
15.0% |
0.0% |
0.4% |
| E2F1 |
Cell cycle, centrosome amplification |
10.6% |
1.2% |
0.1% |
9.3% |
0.0% |
0.6% |
| E2F2 |
Cell cycle, centrosome amplification |
4.9% |
0.0% |
0.4% |
4.5% |
0.0% |
0.0% |
| E2F3 |
Cell cycle, centrosome amplification |
13.7% |
2.3% |
0.2% |
12.8% |
0.0% |
0.2% |
| FOXM1 |
Cell proliferation |
15.2% |
2.8% |
0.1% |
14.5% |
0.0% |
0.6% |
| KLHL12 |
May act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex |
35.2% |
12.9% |
0.0% |
29.7% |
0.4% |
0.3% |
| LRRC59 |
Ribosome binding protein |
20.2% |
7.8% |
0.1% |
19.4% |
0.0% |
0.1% |
| MAPRE1 |
Microtubules, dynactin complex, mitotic centrosomes and spindle microtubules |
19.1% |
1.5% |
0.1% |
18.3% |
0.4% |
0.1% |
| MCL1 |
Anti-apoptotic protein |
19.3% |
14.4% |
0.0% |
9.7% |
0.0% |
0.1% |
| MDM4 |
Binds and inhibits p53, suppresses MDM2 function |
26.4% |
13.9% |
0.0% |
18.3% |
0.0% |
0.3% |
| MYC |
Cell cycle progression, apoptosis |
26.2% |
21.9% |
0.0% |
6.7% |
0.0% |
0.3% |
| NCOA3 |
Histone acetyltransferase, transcriptional co-activator |
21.2% |
3.8% |
0.0% |
16.4% |
0.3% |
4.7% |
| NCOA6 |
Transcriptional co-activator |
17.9% |
2.0% |
0.0% |
14.7% |
1.5% |
1.8% |
| NDC80 (Hec-1) |
Chromosome segregation |
10.3% |
10.3% |
0.5% |
9.5% |
0.0% |
0.4% |
| NDE1 |
Microtubule organization, mitosis and neuronal migration |
14.7% |
4.5% |
0.0% |
11.4% |
0.2% |
0.2% |
| NEK2 |
Centrosome separation, mitotic checkpoint |
29.6% |
12.3% |
0.0% |
21.7% |
0.0% |
0.1% |
| NSL1 |
Kinetochores |
39.4% |
12.0% |
0.0% |
34.6% |
1.0% |
0.5% |
| NUF2 |
Centromere |
26.6% |
12.4% |
0.0% |
19.8% |
0.0% |
0.3% |
| NUP107 |
Nuclear pore complex |
13.3% |
3.3% |
0.0% |
11.3% |
0.4% |
0.9% |
| NUP133 |
Nuclear envelope, kinetochores |
38.9% |
13.7% |
0.0% |
33.6% |
1.0% |
0.3% |
| NUP85 |
Nuclear pore complex |
19.6% |
6.2% |
0.0% |
17.7% |
0.1% |
0.1% |
| PARP1 |
DNA damage response |
37.3% |
13.6% |
0.0% |
29.9% |
0.1% |
0.9% |
| PHB |
Cellular senescence |
16.4% |
8.1% |
0.1% |
14.5% |
0.0% |
|
| PMF1 |
|
25.5% |
11.3% |
0.0% |
18.1% |
0.0% |
0.0% |
| PPP2CB |
Phosphatase, negative control of cell cycle |
24.0% |
1.8% |
4.7% |
5.6% |
15.9% |
0.3% |
| PPP2R5A |
Phosphatase, negative control of cell cycle |
22.6% |
12.0% |
0.0% |
14.7% |
0.0% |
0.1% |
| PPP2R5D |
Phosphatase involved in negative control of cell cycle |
17.8% |
2.1% |
0.3% |
15.1% |
2.2% |
0.4% |
| PRKDC |
DNA double strand break repair and recombination |
24.1% |
6.8% |
0.1% |
18.6% |
0.0% |
2.1% |
| RB1 |
Regulator of the cell cycle, centrosome amplification |
14.7% |
0.2% |
4.5% |
2.9% |
7.6% |
2.3% |
| RBL1 (p107) |
Negative regulator of the cell cycle |
13.9% |
2.1% |
0.1% |
12.4% |
0.0% |
0.8% |
| RPL7 |
Ribosomal protein |
23.2% |
10.4% |
0.1% |
18.1% |
0.0% |
0.1% |
| RPS27 |
Ribosomal protein |
19.2% |
12.2% |
0.0% |
8.9% |
0.0% |
0.0% |
| RPS6KB1 |
Protein synthesis, cell growth, and cell proliferation |
25.0% |
11.0% |
0.0% |
22.5% |
1.2% |
0.4% |
| SDCCAG8 |
Organizing the centrosome |
33.6% |
14.5% |
0.0% |
24.9% |
1.2% |
0.7% |
| SGO1 |
Protects centromeric cohesin from cleavage |
10.3% |
1.2% |
0.1% |
9.7% |
0.0% |
0.2% |
| SKA2 |
Spindle and kinetochore |
21.2% |
9.0% |
0.1% |
18.7% |
0.0% |
0.0% |
| SKP2 |
Ubiquitination, degradation of p27KIP1
|
13.2% |
2.0% |
0.3% |
11.9% |
0.0% |
0.2% |
| TFDP1 |
Binds E2Fs and enhances their DNA binding |
13.5% |
2.6% |
0.5% |
11.2% |
1.1% |
0.5% |
| TK1 |
Thymidine kinase |
14.4% |
6.2% |
0.1% |
11.3% |
0.0% |
0.1% |
| TOM1L1 |
Src activating and signaling molecule |
14.4% |
7.2% |
0.0% |
12.3% |
0.4% |
0.3% |
| TP53 |
Cell cycle arrest, apoptosis, senescence, DNA repair, centrosome amplification |
38.0% |
0.1% |
1.3% |
5.0% |
3.4% |
35.0% |
| Mps1/TTK |
Centrosome duplication, spindle assembly checkpoint |
7.4% |
0.2% |
0.2% |
6.8% |
0.0% |
0.4% |
| TUBGCP3 |
Tubulin gamma complex-associated protein |
16.0% |
2.6% |
0.4% |
10.0% |
4.8% |
0.5% |
| UBE2C |
E2 ubiquitin-conjugating enzyme family, cell cycle progression |
13.2% |
3.2% |
0.1% |
11.2% |
0.0% |
0.0% |
| XRCC6 |
Repair of non-homologous DNA ends |
16.8% |
0.3% |
0.1% |
7.1% |
9.1% |
0.6% |
