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. 2017 Sep 8;8(44):77685–77695. doi: 10.18632/oncotarget.20768

Figure 4. Effect of 4-PBA on CS-induced inflammation in mouse lungs.

Figure 4

Mice were administered with PBS or 4-PBA and then exposed to room air or CS for 3 months. Representative Western blot analyses of IRE1α, GRP78 and CHOP in mouse lungs, and densitometric analyses of IRE1α, GRP78 and CHOP (A and B). Concentrations of KC, MIP-2 (C) and the number of total leukocytes cells, macrophage and neutrophils (D) in bronchoalveloar lavage fluid (BALF). Representative Western blot analyses of phosphorylated-p65 in mouse lungs and densitometric analyses of phosphorylated-p65 (E). Quantification of band intensities were normalized to actin. Bars represent means± SEM from 5 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001 (Student's t-test).