Table 2. Summary of meta-analysis results.
| N | Model | Pooled OR (95% CI) | P value | Heterogeneity (I2, P) | Conclusion | Publication bias | |
|---|---|---|---|---|---|---|---|
| PFO at 3 months | |||||||
| Total | 3 | random | 2.74 (1.33-5.65) | 0.006 | 60.0%, 0.082 | positive | 1.000 |
| China | 2 | fixed | 2.11 (1.30-3.43) | 0.002 | 20.1%, 0.263 | positive | |
| Italy | 1 | — | 6.37 (2.33-17.40) | — | — | positive | |
| Onset to admission ≤ 24h | 2 | random | 3.71 (1.57-8.75) | 0.003 | 55.4%, 0.135 | positive | |
| Onset to admission ≤ 7d | 1 | — | 1.46 (0.65-3.28) | — | — | negative | |
| Sample time-on admission | 2 | random | 3.71 (1.57-8.75) | 0.003 | 55.4%, 0.135 | positive | |
| Sample time-on 2ed morning | 1 | — | 1.46 (0.65-3.28) | — | — | negative | |
| Death at 3 months | |||||||
| Total | 3 | random | 1.58 (0.44-5.68) | 0.486 | 93.3%, <0.001 | negative | 1.000 |
| China | 2 | random | 2.02 (0.27-15.25) | 0.496 | 85.0%, 0.010 | negative | |
| Germany | 1 | — | 0.97 (0.95-1.00) | — | — | negative | |
| Sample time-on admission | 2 | random | 2.17 (0.43-10.97) | 0.350 | 96.6%, <0.001 | negative | |
| Sample time-on 2ed morning | 1 | — | 0.64 (0.15-2.76) | — | — | negative |
PFO: poor functional outcome, N: number of included studies, OR: odds ratio, CI: confidence interval.