Table 1. Genotype distribution of single nucleotide polymorphisms of carbonic anhydrase 9 gene in patients with uterine cervical cancer or normal women.
| Variables | Control (n=327) | Cervical cancer(n=123) | p value | OR (95% CI)b | Adjusted OR(95% CI)c |
|---|---|---|---|---|---|
| rs2071676 | |||||
| GGd | 79 (24.2%) | 26 (22.8%) | 0.109 | 1.00 | 1.00 |
| AG | 171 (52.3%) | 56 (43.6%) | 1.00 (0.58-1.70) | 0.72 (0.39-1.34) | |
| AA | 77 (23.5%) | 41 (33.6%) | 1.62 (0.90-2.90) | 1.27 (0.65-2.48) | |
| GGd | 79 (24.2%) | 26 (22.8%) | 0.500 | 1.00 | 1.00 |
| GA/AA | 248 (75.8%) | 97 (77.2%) | 1.19 (0.72-1.96) | 1.13 (0.63-2.00) | |
| GG/GAd | 250 (76.5%) | 82 (66.7%) | 0.035a | 1.00 | 1.00 |
| AA | 77 (23.5%) | 41 (33.3%) | 1.62 (1.03-2.56) | 1.59 (0.93-2.70) | |
| rs3829078 | |||||
| AAd | 297 (90.8%) | 114 (92.7%) | 0.717 | 1.00 | 1.00 |
| AG | 29 (8.9%) | 9 (7.3%) | 0.81 (0.37-1.76) | 0.84 (0.34-2.06) | |
| GG | 1 (0.3%) | 0 (0%) | u.a. | u.a. | |
| AAd | 297 (90.8%) | 114 (92.7%) | 0.533 | 1.00 | 1.00 |
| AG/GG | 30 (9.2%) | 9 (7.3%) | 0.78 (0.36-1.70) | 0.79 (0.32-1.93) | |
| AA/AGd | 326 (99.7%) | 123 (100%) | 0.539 | 1.00 | 1.00 |
| GG | 1 (0.3%) | 0 (0%) | u.a. | u.a. | |
| rs1048638 | |||||
| CCd | 292 (89.3%) | 98 (79.7%) | 0.011a | 1.00 | 1.00 |
| CA | 33 (10.1%) | 25 (20.3%) | 2.26 (1.28-3.98) | 1.98 (1.03-3.79) | |
| AA | 2 (0.6%) | 0 (0%) | u.a. | u.a. | |
| CCd | 292 (89.3%) | 98 (79.7%) | 0.007a | 1.00 | 1.00 |
| CA/AA | 35 (10.7%) | 25 (20.3%) | 2.13 (1.21-3.73) | 1.92 (1.01-3.65) | |
| CC/CAd | 325 (99.4%) | 123 (100%) | 1.000 | 1.00 | 1.00 |
| AA | 2 (0.6%) | 0 (0%) | u.a. | u.a. | |
| 376deletion393 | |||||
| Ins/Insd | 249 (76.1%) | 96 (78.0%) | 0.651 | 1.00 | 1.00 |
| Ins/del | 76 (23.3%) | 27 (22.0%) | 0.92 (0.56-1.52) | 0.86 (0.47-1.57) | |
| Del/del | 2 (0.6%) | 0 (0%) | u.a. | u.a. | |
| Ins/Insd | 249 (76.1%) | 96 (78.0%) | 0.671 | 1.00 | 1.00 |
| Ins/del or del/del | 78 (23.9%) | 27 (22.0%) | 0.90 (0.55-1.48) | 0.84 (0.46-1.52) | |
| Ins/Ins or ins/deld | 325 (99.4%) | 123 (100%) | 1.000 | 1.00 | 1.00 |
| Del/del | 2 (0.6%) | 0 (0%) | u.a. | u.a. |
Statistical analysis: logistic regression model or chi-square or Fisher's exact tests, ap < 0.05.
bComparison between patients with uterine cervical cancer and control women.
cThe adjusted OR with their 95% CI was estimated by logistic regression models after controlling for age between cancer patients and control women.
dUsed as a reference for comparison to evaluate the odds ratio of other genotypes.
OR, odds ratio; 95% CI, 95% confidence interval. Del, deletion; ins, insertion; u.a., unavailable.