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. 2017 Sep 12;8(44):77872–77882. doi: 10.18632/oncotarget.20845

Figure 2. Antigen distribution pie graphs for each patient by histologic subtype.

Figure 2

Distribution of antigen-positive cells in a tumor area for mesothelin (MSLN), cancer antigen 125 (CA125), and Wilms tumor 1 (WT1) were evaluated and shown in a pie graph for each patient. The blue background represents cases with ≥50% MSLN distribution and the green background represents cases with <50% MSLN distribution and ≥50% of either CA125 or WT1 distribution. Cases without any antigen distribution ≥50% have no colored background. The tumors with ≥50% WT1distribution and <50% MSLN distribution. The 269 pie graphs were divided into four groups—non-pleomorphic epithelioid, pleomorphic epithelioid, biphasic, and sarcomatoid—and sorted by MSLN distribution for tumors with MSLN distribution ≥50%, followed by WT1 distribution in tumors with MSLN distribution <50%. In non-pleomorphic epithelioid MPM cases (n = 185), 87% had ≥50% MSLN distribution and 97% had ≥50% distribution of any single antigen. In pleomorphic epithelioid MPM cases (n = 35), 69% had ≥50% MSLN distribution and 77% had ≥50% distribution of any single antigen. In biphasic MPM cases (n = 26), 35% had ≥50% MSLN distribution and 65% had ≥50% distribution of any single antigen. In sarcomatoid MPM cases (n = 23), 13% had ≥50% MSLN distribution and 43% had ≥50% distribution of any single antigen.