Table 2. Distribution and intensity of cancer antigen expression in epithelioid and non-epithelioid malignant pleural mesothelioma.
| Epithelioid | Non-epithelioid* | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSLN n = 230 (%) | CA125 n = 226 (%) | WT1 n = 226 (%) | MSLN n = 49 (%) | CA125 n = 49 (%) | WT1 n = 49 (%) | |||||||
| Expression | ||||||||||||
| Positive | 215 | (93.5) | 169 | (74.8) | 220 | (97.3) | 28 | (57.1) | 16 | (32.7) | 48 | (98.0) |
| Negative | 15 | (6.5) | 57 | (25.2) | 6 | (2.7) | 21 | (42.9) | 33 | (67.3) | 1 | (2.0) |
| Distribution | ||||||||||||
| ≥50% | 193 | (83.9) | 46 | (20.4) | 162 | (71.7) | 12 | (24.5) | 3 | (6.1) | 22 | (44.9) |
| <50%, >0% | 22 | (9.6) | 123 | (54.4) | 58 | (25.6) | 16 | (32.7) | 13 | (26.6) | 26 | (53.1) |
| Intensity | ||||||||||||
| Strong | 81 | (35.2) | 20 | (8.8) | 71 | (31.4) | 4 | (8.2) | 0 | (0.0) | 11 | (22.5) |
| Moderate | 77 | (33.5) | 62 | (27.4) | 96 | (42.5) | 8 | (16.3) | 2 | (4.1) | 18 | (36.7) |
| Weak | 57 | (24.8) | 87 | (38.5) | 53 | (23.5) | 16 | (32.7) | 14 | (28.6) | 19 | (38.8) |
*Biphasic or sarcomatoid subtypes
CA125, cancer antigen 125; MSLN, mesothelin; WT1, Wilms tumor 1