Figure 3. IL-6 knock-out attenuated side pro-invasive effect induced by the single treatment of either sorafenib or IFN-α.

IL-6 had no effect on tumor invasion; the cell invasion capacity was significantly increased in 24 and 48 hr by single treatment of either sorafenib or IFN-α treatment, which was not observed in the co-treatment group; IL-6 knock-out could attenuate the pro-invasive side effect of single treatment; however the effect was not observed when co-treatment was conducted.