Skip to main content
. 2017 Sep 15;8(44):77915–77927. doi: 10.18632/oncotarget.20946

Figure 4. IL-6 promotes tumor cells apoptosis and enhance the pro-apoptosis effect by combining sorafenib and IFN-α.

Figure 4

(A-C) The cell apoptosis rate of HCCLM3-wt cells was significantly higher than that of HCCLM3-IL6(-) cells for 24 and 48 hr. No significant effect on cell apoptosis was found by either sorafenib or IFN-α in both cell lines. However, the prominently increased cell apoptosis by co-treatment was observed and was significantly attenuated in HCCLM3-IL6(-) cells. (D-E) Higher NO levels was observed in HCCLM3-wt cells as compared with HCCLM3-IL6(-) cells, and highest was observed in combination treatment.