Table 2. The association of polymorphisms in microRNA 30c-1 and microRNA 27a with overall survival.
SNP | Genotypes | Num | MST | Log-rank P value | HR | 95% CI (P value) | aHR | 95% CI (P value) |
---|---|---|---|---|---|---|---|---|
microRNA 30c-1 | AA | 133 | 28.44 | 0.054 | 1.00 | 1.00 | ||
rs928508 | AG | 229 | 23.20 | 1.28 | 1.01–1.61 (0.041) | 1.30 | 1.03–1.65 (0.027) | |
GG | 92 | 21.95 | 1.37 | 1.03–1.83 (0.033) | 1.45 | 1.08–1.94 (0.012) | ||
AG | 229 | 23.20 | 0.592 | 1.00 | 1.00 | |||
GG | 92 | 21.95 | 1.07 | 0.83–1.39 (0.593) | 1.09 | 0.84–1.43 (0.514) | ||
AA/AG | 362 | 25.25 | 0.188 | 1.00 | 1.00 | |||
GG | 92 | 21.95 | 1.18 | 0.92–1.51 (0.190) | 1.24 | 0.96–1.59 (0.097) | ||
AA | 133 | 28.44 | 0.019 | 1.00 | 1.00 | |||
AG/GG | 321 | 22.86 | 1.30 | 1.04–1.62 (0.020) | 1.34 | 1.07–1.67 (0.010) | ||
A allele | 495 | 26.04 | 0.022 | 1.00 | 1.00 | |||
G allele | 413 | 22.63 | 1.18 | 1.02–1.36 (0.023) | 1.21 | 1.05–1.39 (0.009) | ||
microRNA 27a | TT | 247 | 26.27 | 0.033 | 1.00 | 1.00 | ||
rs895819 | CT | 167 | 23.71 | 1.17 | 0.95–1.45 (0.143) | 1.23 | 0.99–1.52 (0.062) | |
CC | 40 | 18.25 | 1.56 | 1.09–2.22 (0.014) | 1.71 | 1.20–2.45 (0.003) | ||
CT | 167 | 23.71 | 0.100 | 1.00 | 1.00 | |||
CC | 40 | 18.25 | 1.35 | 0.94–1.95 (0.102) | 1.44 | 1.00–2.08 (0.050) | ||
CT/TT | 414 | 25.23 | 0.030 | 1.00 | 1.00 | |||
CC | 40 | 18.25 | 1.46 | 1.04–2.05 (0.031) | 1.57 | 1.11–2.21 (0.010) | ||
TT | 247 | 26.27 | 0.041 | 1.00 | 1.00 | |||
CC/CT | 207 | 22.79 | 1.23 | 1.01–1.50 (0.042) | 1.30 | 1.06–1.50 (0.012) | ||
T allele | 661 | 25.62 | 0.011 | 1.00 | 1.00 | |||
C allele | 247 | 22.14 | 1.22 | 1.05–1.43 (0.012) | 1.28 | 1.09–1.49 (0.002) |
*Num: the patients number for each genotype, aHR: adjusted HR for histological type, clinical stage and, receipt of chemotherapy and surgery.