Table 2. SNPs with the lowest P values associated with adverse events (AEs) in chemotherapy cycles 1, 2, and 3.
| SNP | Chr | Position | Closest gene(s) | MAFAE yes | MAFAE no | Raw P value | Corrected P value |
|---|---|---|---|---|---|---|---|
| rs12050587 | 15 | 55335330 | PIGB | 26.8 | 21.3 | 1.0 × 10–4 | 0.03 |
| rs11636687 | 15 | 55312954 | RAB27A | PIGB | 20.5 | 15.6 | 1.2 × 10–4 | 0.03 |
| rs9514827 | 13 | 108267055 | ABHD13 | TNFSF13B | 28.0 | 32.6 | 2.9 × 10–3 | 0.70 |
| rs4261468 | 15 | 55263404 | RAB27A | 24.1 | 20.2 | 4.6 × 10–3 | 1.00 |
| rs2290344 | 15 | 55327598 | PIGB | 13.1 | 10.2 | 6.4 × 10–3 | 1.00 |
| rs12050885 | 15 | 55266426 | RAB27A | 15.2 | 12.2 | 8.2 × 10–3 | 1.00 |
| rs8024695 | 15 | 55347107 | PIGB | 13.3 | 10.7 | 1.9 × 10–2 | 1.00 |
| rs4896870 | 6 | 146506145 | GRM1 | RAB32 | 11.7 | 9.3 | 2.6 × 10–2 | 1.00 |
| rs2595500 | 11 | 6941934 | ZNF215 | 19.1 | 22.1 | 3.6 × 10–2 | 1.00 |
| rs2607659 | 8 | 102227775 | RRM2B | 46.8 | 50.1 | 4.7 × 10–2 | 1.00 |
AE, adverse event; Chr, chromosome; MAF, minor allele frequency; SNP, single nucleotide polymorphism.
The table lists minor allele frequencies (MAFs) as well as raw and corrected P values resulting from comparison between the genetic and clinical logistic regression models (“Gene1 | Gene2” indicates the two genes between which the SNP is located).