Table 4. Conclusions from select studies/trials of intraperitoneal nanoparticle safety.

Nanoparticle	Study	Year	Results
Animal studies
Microspheres	Kohane at al. [40]	2006	Microspheres induced inflammation Liver and splenic sequestration with foamy macrophages
Human studies
Paclimer microspheres	Phase I Trial [25]	2006	Microspheres induced inflammation; study discontinued
Pegylated liposomal Doxorubicin (with HIPEC at the time of CRC)	Phase I trial [71]	2008	Well tolerated
Nanotax®(nanoparticulate paclitaxel	Phase I Trialm [25]	2015	Well tolerated with minimal systemic exposure and reduced toxicity compared to IV paclitaxel