Table 2. Overview of NK-1R antagonist effects in various experimental models.

Antagonist	Type	Model	Main findings	Ref
SP antagonists		Electroshock/ intravenous bicuculline (rats)	Significantly attenuated convulsions	[89]
CP-122,721-1	Non-peptide	KA (i.p. rats)	Possibly decreased seizure activity; Counteracted KA-induced nerve cell death in CA1	[21]
Spantide II and RP-67,580		Bipolar electrode stimulation in DG (rats)	Reduced seizure duration in a dose-dependent manner; Suppressed EEG frequency	[20]
GR205171 (vofopitant)		Electroshock (rats)	Exhibited no anticonvulsant efficacy by itself; Potentiated the anticonvulsant efficacy of lamotrigine and other sodium channel blockers	[91]

KA, kainic acid; EEG, electroencephalographic; DG, dentate gyrus.