Table 4.
Multiparametric criteria for metastasis
| Criteria | Threshold | Odds ratio | Sensitivity | Specificity | Accuracy | PPV | NPV |
|---|---|---|---|---|---|---|---|
| Index tumor >3 cm or VI | – | 23.7 (10.1–55.8) | 94.8 (91.1–97.1) | 56.4 (50.0–62.7) | 78.4 (72.6–83.2) | 74.4 (68.4–79.6) | 89.1 (84.4–92.5) |
| Index tumor >5 cm or VI | – | 26.3 (13.1–52.9) | 86.7 (81.7–90.5) | 80.2 (74.6–84.8) | 83.9 (78.6–88.1) | 85.4 (80.3–89.4) | 81.8 (76.3–86.3) |
| Milan size criteriaa or VI | – | 25.5 (12.1–53.8) | 91.9 (87.6–94.8) | 69.3 (63.1–74.9) | 82.2 (76.8–86.6) | 80.0 (74.4–84.7)) | 86.4 (81.4–90.3) |
| Index tumor >3 cm or AFP | >35 | 19.8 (6.8–57.8) | 97.0 (93.9–98.7) | 37.6 (31.6–44.0) | 71.6 (65.5–77.0) | 67.5 (61.3–73.2) | 90.5 (86.0–93.7) |
| >400 | 23.7 (9.5–58.8) | 95.6 (92.0–97.7) | 52.5 (46.1–58.8) | 77.1 (71.3–82.1) | 72.9 (66.8–78.2) | 89.8 (85.2–93.2) | |
| Index tumor >5 cm or AFP | >35 | 19.8 (8.7–44.6) | 94.1 (90.2–96.5) | 55.4 (49.2–61.7) | 77.5 (71.7–82.5) | 73.8 (67.8–79.1) | 87.5 (82.6–91.2) |
| >400 | 26.3 (12.9–53.7) | 89.6 (85.0–93.0) | 75.3 (69.3–80.4) | 83.5 (78.1–87.7) | 82.9 (77.5–87.2) | 84.4 (79.2–88.6) | |
| Milan size criteriaa or AFP | >35 | 41.5 (12.4–138.9) | 97.8 (94.8–99.2) | 48.5 (42.3–54.9) | 76.7 (70.8–81.7) | 71.7 (65.6–77.2) | 94.2 (90.4–96.7) |
| >400 | 25.3 (11.5–55.7) | 93.3 (89.3–96.0) | 64.4 (58.0–70.2) | 80.9 (75.4–85.5) | 77.8 (72.0–82.7) | 87.8 (88.0–91.5) | |
| Index tumor >3 cm or VI or AFP | >35 | 24.4 (7.2–82.1) | 97.8 (94.8–99.2) | 35.6 (29.8–42.0) | 71.2 (65.0–76.6) | 67.0 (60.7–72.7) | 92.3 (88.1–95.2) |
| >400 | 33.4 (11.5–97.2) | 97.0 (93.9–98.7) | 50.5 (44.1–56.9) | 77.1 (71.3–82.1) | 72.4 (66.3–77.7) | 92.7 (88.6–95.5) | |
| Index tumor >5 cm or VI or AFP | >35 | 27.6 (10.4–73.1) | 96.3 (92.9–98.2) | 51.5 (45.1–57.8) | 77.1 (71.3–82.1) | 72.6 (66.6–78.0) | 91.2 (86.8–94.3) |
| >400 | 34.8 (15.6–77.5) | 93.3 (89.3–96.0) | 71.3 (65.2–76.7) | 83.9 (78.6–88.1) | 81.3 (75.8–85.8) | 88.9 (84.2–92.4) | |
| Milan size criteriaa or VI or AFP | >35 | 55.6 (13.0–237.1) | 98.5 (95.8–99.6) | 45.5 (39.3–52.0) | 75.8 (69.9–80.9) | 70.7 (64.6–76.2) | 95.8 (92.3–97.9) |
| >400 | 34.2 (13.7–85.0) | 95.6 (92.0–97.7) | 61.4 (55.0–67.4) | 80.9 (75.4–85.5) | 76.8 (70.9–81.8) | 91.2 (86.8–94.3) |
Notes:
a
Milan size criteria: one tumor <5 cm or up to three tumors <3 cm with no extrahepatic disease or vascular invasion. Data in parentheses are 95% CIs.
Abbreviations: NPV, negative predictive value; PPV, positive predictive value; VI, vascular invasion.